Am J Cardiovasc Dis 2013;3(3):158-162

Original Article
Effects of pulsatile perfusion during cardiopulmonary bypass on
biochemical markers and kidney function in patients undergoing cardiac
surgeries

Alireza Mohammadzadeh, Naser Jafari, Mohammad Hasanpour, Soheil Sahandifar, Masoud Ghafari, Vahed Alaei

Department of Cardiothoracic, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil 56197, Iran

Received June 10, 2013; Accepted August 2, 2013; Epub August 16, 2013; Published August 30, 2013

Abstract: For several years there is no conclusive guideline on the effectiveness of pulsatile or non-pulsatile perfusion
during cardiopulmonary bypass (CPB) in patients undergoing cardiac surgeries. In this study, we evaluated the effect of
pulsatile versus continuous perfusion on the myocardial release of the cardiac biochemical markers including, creatine
phosphokinase (CPK), cardiac creatine kinase (CK-MB), and lactate dehydrogenase (LDH), and also kidney function tests
including: blood urea nitrogen test (BUN) and creatinine test (Cr) in patients that underwent both pulsatile and
non-pulsatile methods before and after heart surgeries. A total of 80 patients were enrolled in this study, 40 patients in
each pulsatile and non-pulsatile group. Venous blood samples were drown from each patient in two groups before
operation and after operation at, 24, 48, and 72 h and analyzed separately for CPK, its cardiac isoenzyme (CK-MB), LDH,
BUN and Cr. There were no significant differences between the two groups with regard to preoperative parameters such
as sex, age, and body surface area. Our study shows that the effect of pulsatile perfusion on cardiac and kidney function is
better than the non-pulsatile method. (AJCD1306003).

Keywords: Cardiopulmonary bypass, pulsatile, non-pulsatile, biochemical markers, kidney function

Address correspondence to: Dr. Alireza Moham-madzadeh, Department of Cardiothoracic, Imam Khomeini Hospital,
Ardabil University of Medical Sciences, Ardabil 56197, Iran. Tel: +98 (451) 5522089; Fax: +98 (451) 5522089; E-mail:
a.mohammadzadeh@arums.ac.ir
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