Am J Cardiovasc Dis 2013;3(3):129-134

Review Article
The neuroimmune guidance cue netrin-1: a new therapeutic target in
cardiovascular disease

Bongo Bertrand Joseph, Peng Dao Quan

Department of cardiovascular diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011,
PR China

Received May 30, 2013; Accepted June 14, 2013; Epub August 16, 2013; Published August 30, 2013

Abstract: Netrins are a family of proteins involved in cell migration and axon guidance during embryogenesis. The different
functions and mechanisms of action of this family of proteins have been better characterized with the study of the netrin-1.
They are chemotropic and act as a bifunctional regulator of neuron migration. Apart from its role in the central nervous
system, researchers have proven that netrin-1 plays a role in the development and formation of non-neural tissue, thus
netrin-1 is involved in regulation of cancers, cardiovascular diseases, kidney diseases and other diseases. Concerning
the cardio-vascular realm, netrin-1 promotes angiogenesis and accelerates atherosclerosis, protects the heart against
ischemia-reperfusion injury and reduces the infarct size. These findings make the neuroimmune guidance cue netrin-1 an
important therapeutic target. This work seeks to review the subject based on studies that have been conducted over the
past decade to identify the perspectives and extent of the research on this protein in the field of cardiology. (AJCD1305004).

Keywords: Netrin-1, atherosclerosis, angiogenesis, cardioprotection, ischemia-reperfusion injury

Address correspondence to: Dr. Peng Dao Quan, Department of cardiovascular diseases, Second Xiangya Hospital,
Central South University, Changsha, Hunan 410011, PR China. Tel: +86-13974822567; E-mail: pengdq@hotmail.com;
josephbbongo@yahoo.com
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