Am J Cardiovasc Dis 2013;3(3):120-128

Original Article
When heart goes “BOOM” to fast. Heart rate greater than 80 as mortality
predictor in acute myocardial infarction

Goran Davidovic, Violeta Iric-Cupic, Srdjan Milanov, Aleksandra Dimitijevic, Mirjana Petrovic-Janicijevic

Clinic of Cardiology, Clinical Center Kragujevac, Kragujevac, Serbia; Faculty of medical sciences, University in Kragujevac,
Kragujevac, Serbia; Clinic of Ophtalmology, Clinical Center Kragujevac, Serbia

Received April 23, 2013; Accepted May 8, 2013; Epub August 16, 2013; Published August 30, 2013

Abstract: Many prospective studies established association between high heart rate and increased cardiovascular
morbidity and mortality, independently of other risk factors. Heart rate over 80 beats per minute more often leads to
atherosclerotic plaque disruption, the main step in developing acute coronary syndrome. Purpose was to investigate the
incidence of higher heart rate levels in patients with anterior wall acute myocardial infarction with ST-segment elevation
and the influence of heart rate on mortality. Research included 140 patients with anterior wall acute myocardial infarction
with ST-segment elevation treated in Coronary Unit, Clinical Center Kragujevac in the period from January 2001-June 2006.
Heart rate was calculated as the mean value of baseline and heart rate in the first 30 minutes after admission. Other risk
factors were also followed to determine their connection with elevated heart rate. Results showed that the majority of
patients survived (over 70%). In a total number of patients, more than 75% had a heart rate levels greater than 80 beats per
minute. There was a significant difference in heart rate on addmision between survivors and patients who died, with a
greater levels in patients with fatal outcome. Both, univariate and multivariate regression analysis singled out heart rate
greater than 80 beats per minute as independent mortality predictor in these patients. Heart rate greater than 80 beats per
minute is a major, independent risk factor for morbidity and important predictor of mortality in patients with acute
myocardial infarction. (AJCD1304004).

Keywords: Heart rate greater than 80 beats per minute, mortality, acute myocardial infarction

Address correspondence to: Dr. Goran Davidovic, Clinic of Cardiology, Clinical Center Kragujevac, Kopaonicka 5/II, P.Box
22, 34000 Kragujevac, Serbia. Tel: +381 64 67 91 200; Fax: +381 34 370 197; E-mail: medicusbg@yahoo.com;
akreditacija@medf.kg.ac.rs
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