Am J Cardiovasc Dis 2012;2(4):318-322

Original Article
Abdominal aortic aneurysm and the association with serum levels of
Homocysteine, vitamins B6, B12 and Folate

Markus Lindqvist, Anders Hellström, Anders E Henriksson

Department of Laboratory Medicine, Sundsvall County Hospital, Sweden; Department of Applied Science and Design, Mid
Sweden University, Sweden

Received September 4, 2012; accepted October 5, 2012; Epub October 25, 2012; Published November 15, 2012

Abstract: Previous investigations have shown hyperhomocysteinemi in patients with abdominal aortic aneurysm (AAA). In
the present study we evaluated the circulating level of homocysteine (Hcy) in relation to renal function, vitamins B6, B12 and
folate status in AAA patients with special regard to aneurysm size, and rupture. Hcy, Creatinine, B6, B12 and folate were
measured in 119 patients with AAA and 36 controls without aneurysm matched by age, gender and smoking habit. As
expected there was a weak correlation between Hcy and vitamins B6, B12 or folate. We found similar levels of Hcy, B6 and
folic acid in patients with nonruptured AAA compared to the control group matched by age, gender and smoking habit.
There was no correlation between maximum diameter of the nonruptured AAA (n=78) and Hcy, B6 or folate. However, the
present study shows a significant inverse correlation between maximum diameter of the nonruptured AAA (n=78) and B12
(r = -0.304, p=0.007) with significant higher levels in small AAA compared to large AAA. In conclusion, Hcy does not seem
to be a useful biomarker in AAA disease. The unexpected finding of B12 levels correlating to aneurysm diameter warrants
urgent further investigation of B12 supplement to prevent progression of small AAA. (AJCD1209001).

Keywords: Homocysteine, C-reactive protein, vitamin B6, vitamin B12, folate, aneurysm, aorta

Address all correspondence to:
Dr. Anders Henriksson
Laboratory Medicine
Sundsvall County Hospital
SE-851 86 Sundsvall, Sweden.
Tel: +46 60 181379; Fax: +46 60 182230
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