Am J Cardiovasc Dis 2012;2(4):253-266

Review Article
The cardio-protective signaling and mechanisms of adiponectin

Gayani Nanayakkara, Thiruchelvan Kariharan, Lili Wang, Juming Zhong, Rajesh Amin

Department of Pharmacal Sciences, Harrison School of Pharmacy, the PPAR & Metabolic Research, Lab, Auburn
University, Auburn, Alabama; Department of Anatomy, Physiology and Pharmacology, Auburn University, Alabama, USA.

Received August 9, 2012; accepted October 4, 2012; Epub October 20, 2012; Published November 15, 2012

Abstract: Adiponectin is an endogenous insulin-sensitizing hormone which has been found to regulate energy
metabolism throughout the body, including the heart. However, low levels of adiponectin are found in patients with
diabetes, hypertension and cardiovascular diseases. Thus it has been suggested to be an independent predictor for
cardiovascular risk. Paradoxically, recent studies have also determined that adiponectin has cardioprotective effects
against various cardiac related pathologies which lead to heart failure. These cardioprotective effects of adiponectin are
attributed to its anti-inflammatory, anti-oxidant and anti-apoptotic properties. Further findings suggest that locally produced
adiponectin in cardiomyocytes are functional and biologically significant. This ectopic derived adiponectin exerts its
protective effects through an autocrine mechanism. These data suggest adiponectin may serve as a potential therapeutic
target against the development of pathologies which develop into heart failure. The current manuscript has summarized
the key findings to date which explore the cardioprotective mechanisms of adiponectin against various cardiac pathologies.
Further we explore the roles of both circulating and endogenous heart specific adiponectin and their physiological
importance in various heart diseases. (AJCD1208002).

Keywords: Adiponectin, diabetes, diabetic cardiomyopathy, ischemia reperfusion, myocardial infarction

Address all correspondence to:
Dr. Rajesh Amin
The PPAR and Metabolic Research Lab
Department of Pharmacal Sciences
326 West Thach Ave, 3211E Walker Building
Auburn University, Auburn, Alabama 36849, USA.
Tel: 334-344-8295
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