Am J Cardiovasc Dis 2012;2(4):301-308

Original Article
Safety and efficacy of the Aperio thrombectomy device when compared to
the Solitaire AB/FR and the Revive devices in a pulsatile flow system

Mahdi Saleh, John Nathan Spence, Sanjeev Nayak, Gillian Pearce, Christopher Tennuci, Christine Roffe

From the Acute Stroke Unit, University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom; Department of
Interventional Neuroradiology, University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom; Institute for
Science and Technology in Medicine, Keele University, Stoke-on-Trent, United Kingdom; the Stoke Stroke Research Group,
Stoke-on-Trent, United Kingdom

Received July 27, 2012; accepted October 3, 2012; Epub October 25, 2012; Published November 15, 2012

Abstract: Background and Purpose: There are a limited number of studies comparing the Aperio mechanical
thrombectomy device to other stent-based devices. In this paper, we compared the Aperio thrombectomy device to the
Solitaire AB, FR and Revive devices in a model of the middle cerebral artery (MCA) within a modified pulsatile flow system.
Methods: Thrombi made of lamb’s blood were placed into a pulsatile flow system perfused with Hartmann’s solution at 80
bpm with a mean pressure of 90 mm Hg. 30 experiments were run with each device. Results: Recanalization rates were
similar for all three devices (90% with the Solitaire AB, FR, 80% with the Revive, and 90% with the Aperio). The mean
number of attempts to retrieve the thrombus was also similar for all three devices (1.7 with the Solitaire AB, FR, 2.1 with the
Revive, 1.6 with the Aperio). Clot fragmentation and embolization rates revealed no statistical significance but there was a
trend towards lower embolization rates with the Aperio (23% compared to 40% with the Solitaire AB, FR and 47% with the
Revive). The Aperio was the fastest to recanalize the MCA (mean of 66 seconds compared to 186 seconds for the Solitaire
AB, FR and 169 seconds for the Revive). Conclusions: In this in vitro setting, the Aperio device seems to be an efficacious
and safe device when compared to other similar clinically used mechanical thrombectomy devices. Larger clinical trials
are warranted. (AJCD1207003).

Keywords: Stroke, mechanical thrombectomy, flow model, Aperio


Address all correspondence to:
Dr. Christine Roffe
Acute Stroke Unit
University Hospital of North Staffordshire
Stoke-on-Trent, ST4 6QG, United Kingdom.
Tel: 00447740372852;
E-mail: Christine.roffe@northstaffs.nhs.uk
AJCD Copyright © 2011-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA