Am J Cardiovasc Dis 2012;2(2):143-149

Review Article
Adipocyte dysfunction and hypertension

Junlan Zhou, Gangjian Qin

Feinberg Cardiovascular Research Institute, Department of Medicine – Cardiology, Northwestern Univesity Feinberg
School of Medicine, Chicago, IL, USA

Received March 18, 2012; accepted April 27, 2012; Epub May 15, 2012; Published June 15, 2012

Abstract: Obesity is increasingly a public health problem due to its high risk of developing insulin resistance, diabetes,
atherosclerosis, hypertension, chronic kidney disease, and increased cardiovascular morbidity and mortality. In particular,
the association of obesity and hypertension is well recognized; however, the underlying mechanisms are not fully
understood. This article reviews recent advancements of cellular and molecular mechanisms by which adipocyte
dysfunction and obesity contribute to hypertension through endocrine and paracrine effects of the adipose tissue-derived
adipokines on the function of vascular endothelial cells, smooth muscle cells and macrophages. (AJCD1203005).

Keywords: Obesity, adipocyte, adipokine, vascular function, hypertension

Address all correspondence to:
Dr. Gangjian Qin
Feinberg Cardiovascular Research Institute
Department of Medicine-Cardiology
Northwestern University Feinberg School of Medicine
303 E Chicago Ave., Tarry 14-751, Chicago, IL 60611, USA.
Tel: (312) 503-1652; Fax: (312) 503-0137
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