Am J Cardiovasc Dis 2011;1(3):274-292

Review Article
Cardioproteomics: advancing the discovery of signaling mechanisms
involved in cardiovascular diseases

Ziyou Cui, Shannamar Dewey, Aldrin V. Gomes

Department of Neurobiology, Physiology and Behavior, Molecular, Cellular and Integrative Physiology Graduate Program,
Department of Physiology and Membrane Biology, University of California, Davis, CA 95616, USA.

Received August 8, 2011; accepted August 29, 2011; Epub September 10, 2011; published September 30, 2011

Abstract: Cardioproteomics (Cardiovascular proteomics) is fast becoming an indispensible technique in deciphering
changes in signaling pathways that occur in cardiovascular diseases (CVDs). The quality and availability of the
instruments and bioinformatics software used for cardioproteomics continues to improve, and these techniques are now
available to most cardiovascular researchers either directly or indirectly via university core centers. The heart and aorta are
specialized tissues which present unique challenges to investigate. Currently, the diverse range of proteomic techniques
available for cardiovascular research makes the choice of the best method or best combination of methods for the disease
parameter(s) being investigated as important as the equipment used. This review focuses on proteomic techniques and
their applications that advanced our understanding of the signaling mechanisms involved in CVDs at the levels of protein
complex/protein-protein interaction, post-translational modifications and signaling induced protein changes.

Key words: Cardioproteomics, cardiovascular diseases, signaling pathway, proteomics, heart, mass spectrometry, drug

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Address all correspondence to:
Dr. Aldrin V. Gomes
176 Briggs Hall, One Shields Avenue
Department of Neurobiology, Physiology and Behavior
University of California, Davis, CA 95616, USA.
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