Am J Cardiovasc Dis 2011;1(3):236-243
Review Article
Emerging concept of anti-hypertensive therapy based on ambulatory blood
pressure profile in chronic kidney disease
Kouichi Tamura, Tomohiko Kanaoka, Masato Ohsawa, Sona Haku, Kengo Azushima, Akinobu Maeda, Toru Dejima,
Hiromichi Wakui, Motoko Ozawa, Atsu-ichiro Shigenaga, Yoshiyuki Toya, Satoshi Umemura
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine,
Yokohama, Japan.
Received July 22, 2011; accepted July, 2011; Epub July, 2011; published August 30, 2011
Abstract: Presently hypertensive patients with chronic kidney disease (CKD) particularly diabetic nephropathy are
increasing in number, and cardiovascular and renal complications are the most common cause of death in these patients.
The control of blood pressure (BP) is an important issue in cardiovascular and renal protection in hypertensive patients
with CKD. Although hypertension is usually diagnosed based on measurements of BP recorded during a visit to a
physician, that is, office BP, several studies have shown that target organ damage and prognosis are more closely
associated with ambulatory BP than with office BP. It should be important to achieve the target absolute BP levels in
hypertensive patients obtained either by office or home mesurements or by ambulatory recordings for the cardiovascular
and renal protection. Noninvasive techniques for measuring ambulatory BP have allowed BP to be monitored during both
day and night. Additionally, ambulatory BP monitoring can provide information on circadian BP variation, short-term BP
variability, which are suggested to be associated with cardiovascular and renal morbidity and mortality. This review will
briefly summarize the emerging concept of anti-hypertensive therapy based on ambulatory BP profile in hypertensive
patients with CKD. (AJCD1107006).
Keywords: Blood pressure variability, diabetic nephropathy, hypertension, chronic kidney disease, renin-angiotensin
system
Full Text PDF
Address all correspondence to:
Kouichi Tamura, MD, PhD
Department of Medical Science and Cardiorenal Medicine
Yokohama City University Graduate School of Medicine
3-9 Fukuura, Kanazawa-ku
Yokohama 236-0004, Japan.
Tel: +81-45-787-2635
Fax: +81-45-701-3738
E-mail: tamukou@med.yokohama-cu.ac.jp
Review Article
Emerging concept of anti-hypertensive therapy based on ambulatory blood
pressure profile in chronic kidney disease
Kouichi Tamura, Tomohiko Kanaoka, Masato Ohsawa, Sona Haku, Kengo Azushima, Akinobu Maeda, Toru Dejima,
Hiromichi Wakui, Motoko Ozawa, Atsu-ichiro Shigenaga, Yoshiyuki Toya, Satoshi Umemura
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine,
Yokohama, Japan.
Received July 22, 2011; accepted July, 2011; Epub July, 2011; published August 30, 2011
Abstract: Presently hypertensive patients with chronic kidney disease (CKD) particularly diabetic nephropathy are
increasing in number, and cardiovascular and renal complications are the most common cause of death in these patients.
The control of blood pressure (BP) is an important issue in cardiovascular and renal protection in hypertensive patients
with CKD. Although hypertension is usually diagnosed based on measurements of BP recorded during a visit to a
physician, that is, office BP, several studies have shown that target organ damage and prognosis are more closely
associated with ambulatory BP than with office BP. It should be important to achieve the target absolute BP levels in
hypertensive patients obtained either by office or home mesurements or by ambulatory recordings for the cardiovascular
and renal protection. Noninvasive techniques for measuring ambulatory BP have allowed BP to be monitored during both
day and night. Additionally, ambulatory BP monitoring can provide information on circadian BP variation, short-term BP
variability, which are suggested to be associated with cardiovascular and renal morbidity and mortality. This review will
briefly summarize the emerging concept of anti-hypertensive therapy based on ambulatory BP profile in hypertensive
patients with CKD. (AJCD1107006).
Keywords: Blood pressure variability, diabetic nephropathy, hypertension, chronic kidney disease, renin-angiotensin
system
Full Text PDF
Address all correspondence to:
Kouichi Tamura, MD, PhD
Department of Medical Science and Cardiorenal Medicine
Yokohama City University Graduate School of Medicine
3-9 Fukuura, Kanazawa-ku
Yokohama 236-0004, Japan.
Tel: +81-45-787-2635
Fax: +81-45-701-3738
E-mail: tamukou@med.yokohama-cu.ac.jp
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