Review Article S100/calgranulins EN-RAGEing the blood vessels: implications for inflammatory responses and atherosclerosis
Marion A Hofmann Bowman, Ann Marie Schmidt
Department of Medicine, The University of Chicago, Chicago, IL, USA; Department of Medicine, New York University, New York, NY, USA.
Received May 6, 2011; accepted May 17, 2011; Epub May 20, 2011; published June 1, 2011
Abstract: Atherosclerosis remains the leading cause of death in the western countries and represents a complex chronic inflammatory process whose regulation is dependent on a network of cytokine and chemokine signaling between key cells such as endothelial cells, monocytes, dendritic cells, lymphocytes and smooth muscle cells. This review focuses on the biology and function of S100 proteins and their receptor RAGE with respect to the multifactorial process leading to atherosclerosis, plaque rupture, and aortic wall remodeling. (AJCD1105003).
Keywords: Atherosclerosis, vascular inflammation, S100 proteins, S100A12, Receptor for advanced glycation endproducts (RAGE), mouse models of human disease
Address all correspondence to: Dr. Marion Hofmann Bowman The University of Chicago 5841 S. Maryland Avenue MC 6088 Chicago Il 60637 Tel: 773 834 0807 Fax: 773 702 2681 E-mail: firstname.lastname@example.org