Am J Cardiovasc Dis 2011;1(1):92-100

Review Article
S100/calgranulins EN-RAGEing the blood vessels: implications for
inflammatory responses and atherosclerosis

Marion A Hofmann Bowman,  Ann Marie Schmidt

Department of Medicine, The University of Chicago, Chicago, IL, USA; Department of Medicine, New York University, New
York, NY, USA.

Received May 6, 2011; accepted May 17, 2011; Epub May 20, 2011; published June 1, 2011

Abstract: Atherosclerosis remains the leading cause of death in the western countries and represents a complex chronic
inflammatory process whose regulation is dependent on a network of cytokine and chemokine signaling between key cells
such as endothelial cells, monocytes, dendritic cells, lymphocytes and smooth muscle cells. This review focuses on the
biology and function of S100 proteins and their receptor RAGE with respect to the multifactorial process leading to
atherosclerosis, plaque rupture, and aortic wall remodeling. (AJCD1105003).

Keywords: Atherosclerosis, vascular inflammation, S100 proteins, S100A12, Receptor for advanced glycation endproducts
(RAGE), mouse models of human disease

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