Am J Cardiovasc Dis 2011;1(1):38-47

Original Article
Cardioprotection by resveratrol: a review of effects/targets in cultured cells
and animal tissues

Joseph M Wu, Tze-chen Hsieh, Zhirong Wang

Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA; Department of
Cardiology, Affiliated Hospital of Zuzhou Medical College, Xuzhou, Jiangsu, China

Received April 1, 2011; accepted April 26, 2011; Epub April 27, 2011; published June 1, 2011

Abstract: The most widespread form of cardiovascular disease (CVD) in the western world today is atherosclerosis (AS),
notably of the major arteries. Despite decades of laboratory, animal, and clinical investigation providing multiple leads and
intervention strategies that have resulted in a progressive decline in CVD-related mortality rates, the etiology of AS is
incomplete; hence, the need for management and prevention remains imperative. AS is initiated by endothelial cell (EC)
injury whereas its progression is promoted by EC interaction with cells that are recruited to the injured endothelium, and
additionally, bioactive cytokines and chemokines elaborated by the intercellular interplay. A primary research interest of our
laboratory has been the mechanisms that underlie the “French paradox” -- an epidemiological association of the co-
existence of risk factors with low CVD incidence/mortality rates postulated to attribute to low-to-moderate consumption of
red wine and grape-derived polyphenol resveratrol. This review summarizes effects and targets of resveratrol in cultured
human aortic and pulmonary aortic endothelial cells (HAEC and HPAEC) and animal tissues, with focus on the resveratrol
target protein RTP, N-ribosyldihydro-nicotinamide:quinone oxidoreductase (NQO2). (AJCD1104001).

Keywords: Resveratrol, cardioprotection, RTPs (resveratrol target proteins), human endothelial cells, Wistar rat tissues

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Address all correspondence to:
Dr. Joseph M. Wu
Department of Biochemistry & Molecular Biology
New York Medical College
Valhalla, New York 10595,
USA
Tel: 914-594-4891
Fax: 914-594-4058
Email:
Joseph_Wu@nymc.edu
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